TRANSFUSION MEDICINE AND IMMUNO HAEMATOLOGY

Publications:

  1. Viswabandya A, Baidya S, Nair SC, Abraham A, George B, Mathews V, Chandy M, Srivastava A. Correlating clinical manifestations with factor levels in rare bleeding disorders: a report from Southern India. Haemophilia. 2012 May;18(3):e195-200
  2. Chendamarai E, Balasubramanian P, George B, Viswabandya A, Abraham A, Ahmed R, Alex AA, Ganesan S, Lakshmi KM, Sitaram U, Nair SC, Chandy M, Janet NB, Srivastava VM, Srivastava A, Mathews V. Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy. Blood 2012 Apr 12;119(15):3413-9.
  3. Edison ES, Sathya M, Rajkumar SV, Nair SC, Srivastava A, Shaji RV. G A novel β-globin gene mutation HBB.c.22>C produces a hemoglobin variant (Hb Vellore) mimicking HbS in HPLC. Int J Lab Hematol. 2012 Oct;34(5):556-8.
  4. Gorczyca ME, Nair SC, Jilma B, Priya S, Male C, Reitter S, Knoebl P, Gilbert JC, Schaub RG, McGinness KE, Pabinger I, Srivastava A. Inhibition of tissue factor pathway inhibitor (TFPI) by the aptamer BAX499 improves clotting of hemophiliac blood and plasma.  J Thromb Haemost. 2012 Aug;10(8):1581-90.
  5. David S, Jayandharan GR, Abraham A, Rr J, Devi GS, Patkar N, Shaji RV, Nair SC, Viswabandya A, Ahmed R, George B, Mathews V, Chandy M, Srivastava A. Molecular basis of Wiskott-Aldrich syndrome in patients from India. Eur J Haematol. 2012 Oct;89(4):356-60. (Letter)
  6. Siromani U, Rajaiah M, Daniel D, Mammen JJ, Nair SC. Ahead to 100% of voluntary nonremunerated blood donation at a tertiary referral hospital blood bank in South India. Asian J Transfus Sci. 2012 Jul;6(2):190 
  7. Sajith KG, Goel A, Ramachandran J, Priya S, Nair SC, Eapen CE. Erythrocytosis as a cause of false increase in prothrombin time and activated partial thromboplastin time. Indian J Gastroenterol. 2012 Nov 1. [Epub ahead of print]
  8. Sen D, Gadkari RA, Sudha G, Gabriel N, Sathish Kumar Y, Selot R, Samuel R, Rajalingam S, Ramya V, Nair SC, Srinivasan N, Srivastava A, Jayandharan GR. Targeted modifications in adeno-associated virus (AAV) serotype -8 capsid improves its hepatic gene transfer efficiency in vivo. Hum Gene Ther Methods. 2013 Apr;24(2):104-16
  9. Goel A, Nair SC, Viswabandya A, Masilamani VP, Rao SV, George A, Regi A, Jose R, Zachariah U, Subramani K, Eapen CE, Chandy G. Preliminary experience with use of recombinant activated factor VII to control postpartum hemorrhage in acute fatty liver of pregnancy and other pregnancy-related liver disorders. Indian J Gastroenterol. 2013 Jul;32(4):268-71
  10. Sumitha E, Jayandharan GR, Arora N, Abraham A, David S, Sankari Devi G, Shenbagapriya P, Nair SC, George B, Mathews V, Chandy M, Viswabandya A, Srivastava A. Molecular basis of quantitative fibrinogen disorders in 27 patients from India. Haemophilia. 2013 Jul;19(4):611-8
  11. Shima M, Thachil J, Nair SC, Srivastava A. Towards standardization of the clot waveform analysis and recommendations for its clinical applications.  J Thromb Haemost. 2013 Jul;11(7):1417-20.
  12. Siromani U, Tsubaki T, Daniel D, Mammen JJ, Nair SC. Perspectives and attitudes to voluntary blood donation in a tertiary referral hospital blood bank. Asian J Transfus Sci. 2013 Jul;7(2):158-9. 25.
  13. Varghese J, Chacko MP, Rajaiah M, Daniel D. Red cell alloimmunization among antenatal women attending a tertiary care hospital in south India. Indian J Med Res. 2013;138:68-71
  14. MP Chacko, A Mathan, D Daniel, G Basu, S Varughese. Significance of pre-transplant anti-HLA antibodies detected on an ELISA mixed antigen tray platform. Indian Journal of Nephrology 2013;23:351-3.
  15. Vandana Kamath, Parimal Sarda, Mary Purna Chacko, Usha sitaram Pseudothrombocytopenia observed with ethylene diamine tetra acetate and citrate        anticoagulants, resolved using 37 dregree incubation and Kanamycin: A case report. Indian journal of Pathol and Microbiology 2013;56:306-8.

Conferences attended by staff:

1) TRANSMEDCON:Annual conference of Indian Society of Transfusion Medicine in September

Papers presented:

  1. Prevalence of platelet crossmatch positivity among pediatric oncology patients at a tertiary care centre in South India. Presented by Dr Kingsley, final year MD Transfusion Medicine student. Awarded first prize among oral papers.
  2. Nucleic acid testing versus quantitative PCR – where do we stand?. Presented by Dr Eliza, final year MD Transfusion Medicine student. Awarded first prize among posters in the category.
  3. An ABO mismatched renal transplant recipient with anti HLA antibody – the single antigen bead assay, the step forward. Presented by Dr Rani, final year MD Transfusion Medicine student. Awarded second prize among posters in the category
  4. Value addition to the complement dependent cytotoxicity crossmatch through the antihuman globulin assay. Presented as a poster by Ms R Santhi, instructor, MLT
  5. Anti M in an antenatal setting: a cause for worry. Report of two cases. Poster presented by Mr Amal Raj, instructor, MLT
  6. Skewed lyonisation ofX chromosomes in a hemophilic female carrier -a case report. Poster presented by Dr Parmatama Tripadi, 2nd year MD Transfusion Medicine student
  7. Solving blood group discrepancies – the role of molecular genotyping. Poster presented by Dr Soonam, 2nd year MD Transfusion Medicine student
  8. Relevance of MFI values of DSA in renal transplant patients undergoing desensitization. What does it tell us? Oral paper by Dr Jui, 2nd year MD Transfusion Medicine student
  9. Impact of pre transplant donor specific antibody (DSA) detected on the Luminex platform on outcome in renal transplantation. Oral paper presented by Dr Mary Purna Chacko, Associate Professor

2) Conference of Indian Society of HLA and Immunogenetics in October

Papers presented

  1. History of sensitizing events- a correlate with anti HLA antibodies as detected on the ELISA platform. Oral paper presented by Mr Sam Aruldoss. Awarded first prize among free papers.
  2. How robust is Luminex methodology for HLA typing. Oral paper presented by Ms Anudha Augustin

3)Annual conference of Indian Society of Hematology and Transfusion Medicine in November

Papers presented:

  1. Acquired hemophilia A – a rare bleeding disorder. Oral paper presented by Dr Nitin, post graduate fellow in laboratory hematology
  2. Evaluation of patients with mucocutaneous bleeding in a tertiary hospital in India. Oral paper presented by Dr Gayatri, post graduate fellow in laboratory hematology
  3. Type 2B vs platelet type VWD – a diagnostic challenge in a tertiary care centre. Oral presentation by Dr Vandana Kamath

Research work:

Initiated:

  1. Prevalence of IgG subtypes (IgG1/G3) in antenatal allo immunized women in a tertiary hospital in South India. Post graduate thesis. Principal Investigator: Dr Jui Choudhuri, Guide: Dr Dolly Daniel
  2. Comparative evaluation of rotational thromboelastometry with standard coagulation profile in acquired bleeding disorder cases. Post graduate thesis.Principal Investigator: Dr Soonam John, Guide: Dr Sukesh C Nair
  3. To study the role and diagnostic accuracy of molecular markers of coagulation and fibrinolysis, namely TAT (Thrombin Antithrombin Comlex), Plasmin/ α2 plasmininhibitor complex, thrombomodulin, tissue plasminogen activator/plasminogen activator inhibitor 1 complex (t-PAI-C) in DIC. Principal investigator: Dr Sukesh C Nair

Completed:

  1. Prevalence of platelet crossmatch positivity among pediatric oncology patients in a tertiary care centre in South India. Post graduate thesis. Principal investigator: Dr Kingsley. Guide: Dr Dolly
  2. Anemia and transfusion decisions in the intensive care units. Post graduate thesis. Principal investigator: Dr Eliza Koshy. Guides: Dr Dolly, Dr J V Peter
  3. Comparative evaluation of the two cell panel with the standard three cell panel in detection of suspected red cell antibodies. Post graduate thesis. Principal investigator: Dr Rani. Guide: Dr Dolly
  4. HLA haplotype frequency analysis wihtin India: pre requisite for bone marrow donor registry and cord blood bank planning. Indo US project under Dr Dolly Daniel